Estrogen signaling in the regulation of female reproductive functions.

نویسندگان

  • J K Findlay
  • S H Liew
  • E R Simpson
  • K S Korach
چکیده

Estrogens influence fertility and infertility in animals. This chapter reviews the use of estrogen as a contraceptive through the regulation of its production and action. It is concluded that the use of specific agonists and antagonists of estrogen action that avoid the global and unwanted side effects of estrogen offers new potential methods of contraception.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The many faces of estrogen signaling

Estrogens have long been known as important regulators of the female reproductive functions; however, our understanding of the role estrogens play in the human body has changed significantly over the past years. It is now commonly accepted that estrogens and androgens have important functions in both female and male physiology and pathology. This is in part due to the local synthesis and action...

متن کامل

Estrogens Receptors-New Players in Spermatogenesis

The mammalian testis is a complex organ that serves two important functions, synthesis of steroids, with significant amount of estrogenic hormones produced and production of spermatozoa. Estrogen receptors (ERs) are expressed in cells of the testis as well as the epididymal epithelium. We have demonstrated that estrogen receptor expression is higher in reproductive tissues as compared to non-re...

متن کامل

Genistein Disrupts Glucocorticoid Receptor Signaling in Human Uterine Endometrial Ishikawa Cells

BACKGROUND The link between environmental estrogen exposure and defects in the female reproductive tract is well established. The phytoestrogen genistein is able to modulate uterine estrogen receptor (ER) activity, and dietary exposure is associated with uterine pathologies. Regulation of stress and immune functions by the glucocorticoid receptor (GR) is also an integral part of maintaining rep...

متن کامل

P-147: Effect of Phoenix Dactylifera Pit Powder on Reproductive Physiology in Female Rat

Background: The pit of Phoenix dactylifera contains different compounds such as saturated and unsaturated fatty acids, Zinc, Cadmium, Calcium and Potassium which could improve steroidogenesis. In this research, effect of phoenix dactylifera pit powder was evaluated on female rat reproduction. Materials and Methods: In this experimental study, 50 female wistar rats were divided in 5 groups of 10...

متن کامل

Functions and physiological roles of two types of estrogen receptors, ERα and ERβ, identified by estrogen receptor knockout mouse

Estrogens, a class of steroid hormones, regulate the growth, development, and physiology of the human reproductive system. Estrogens also involve in the neuroendocrine, skeletal, adipogenesis, and cardiovascular systems. Estrogen signaling pathways are selectively stimulated or inhibited depending on a balance between the activities of estrogen receptor (ER) α or ERβ in target organs. ERs belon...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Handbook of experimental pharmacology

دوره 198  شماره 

صفحات  -

تاریخ انتشار 2010